349 Hepatic fibrogenesis requires sympathetic neurotransmitters
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چکیده
منابع مشابه
Hepatic fibrogenesis requires sympathetic neurotransmitters.
BACKGROUND AND AIMS Hepatic stellate cells (HSC) are activated by liver injury to become proliferative fibrogenic myofibroblasts. This process may be regulated by the sympathetic nervous system (SNS) but the mechanisms involved are unclear. METHODS We studied cultured HSC and intact mice with liver injury to test the hypothesis that HSC respond to and produce SNS neurotransmitters to promote ...
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Background and aims: Hepatic stellate cells (HSC) are activated by liver injury to become proliferative fibrogenic myofibroblasts. This process may be regulated by the sympathetic nervous system (SNS) but the mechanisms involved are unclear. Methods: We studied cultured HSC and intact mice with liver injury to test the hypothesis that HSC respond to and produce SNS neurotransmitters to promote ...
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a w C t a g o l ubstantial improvements in the treatment of hronic liver disease have accelerated interest in unovering the mechanisms underlying hepatic fibrosis nd its resolution. Activation of resident hepatic stelate cells into proliferative, contractile, and fibrogenic ells in liver injury remains a dominant theme driving he field. However, several new areas of rapid rogress in the past 5–...
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Neuroblastomas arise from precursors of sympathetic neurons due to defects in their normal development (Edsjo et al., 2007). Consequently, the tumors exhibit various degrees of neuronal differentiation manifested by expression of markers characteristic for sympathetic neurons and release of their physiological neurotransmitters (Bourdeaut et al., 2009). Since the levels of neuroblastoma cell di...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2003
ISSN: 0270-9139
DOI: 10.1016/s0270-9139(03)80392-0